Developmentally Regulated Post-translational Modification of Nucleoplasmin Controls Histone Sequestration and Deposition
Nucleoplasmin (Npm) is an abundant histone chaperone in vertebrate oocytes and embryos.During embryogenesis, regulation of Npm histone binding is critical for its function in storing and releasing maternal histones to establish and maintain the zygotic Sunglasses epigenome.Here, we demonstrate that Xenopus laevis Npm post-translational modification